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1

Glucocorticoid receptor-dependent induction of cripto-1 (one-eyed pinhead) inhibits zebrafish caudal fin regeneration

Garland, Michael A., Sengupta, Sumitra, Mathew, Lijoy K., Truong, Lisa, de Jong, Esther, Piersma, Aldert H., La Du, Jane, Tanguay, Robert L.

Journal:

Toxicology Reports

Year:

2019

Language:

english

File:

PDF, 6.21 MB

english, 2019

2

Validation of the Rat Limb Bud Micromass Test in the International ECVAM Validation Study on Three In Vitro Embryotoxicity Tests

Spielmann, Horst, Genschow, Elke, Brown, Nigel A., Piersma, Aldert H., Verhoef, Aart, Spanjersberg, Marielle Q.I., Huuskonen, Hannele, Paillard, Francoise, Seiler, Andrea

Journal:

Alternatives to laboratory animals : ATLA

Year:

2004

File:

PDF, 220 KB

2004

3

Exposure-Based Validation List for Developmental Toxicity Screening Assays

Daston, George P., Beyer, Bruce K., Carney, Edward W., Chapin, Robert E., Friedman, Jan M., Piersma, Aldert H., Rogers, John M., Scialli, Anthony R.

Journal:

Birth Defects Research Part B: Developmental and Reproductive Toxicology

Year:

2014

Language:

english

File:

PDF, 92 KB

english, 2014

4

Culture Conditions Affect Chemical-Induced Developmental Toxicity In Vitro : The Case of Folic Acid, Methionine and Methotrexate in the Neural Embryonic Stem Cell Test

de Leeuw, Victoria C., van Nieuwland, Marieke, Bokkers, Bas G.H., Piersma, Aldert H.

Journal:

Alternatives to laboratory animals : ATLA

Year:

2020

File:

PDF, 1.75 MB

2020

5

Integrated approaches to testing and assessment (IATA) in developmental toxicology

Piersma, Aldert H.

Journal:

Reproductive Toxicology

Year:

2017

Language:

english

File:

PDF, 44 KB

english, 2017

6

A comparison of the embryonic stem cell test and whole embryo culture assay combined with the BeWo placental passage model for predicting the embryotoxicity of azoles

Dimopoulou, Myrto, Verhoef, Aart, Gomes, Caroline A., van Dongen, Catharina W., Rietjens, Ivonne M.C.M., Piersma, Aldert H., van Ravenzwaay, Bennard

Journal:

Toxicology Letters

Year:

2018

Language:

english

File:

PDF, 1.01 MB

english, 2018

7

Testing developmental toxicity in a second species: are the differences due to species or replication error?

Braakhuis, Hedwig M., Theunissen, Peter T., Slob, Wout, Rorije, Emiel, Piersma, Aldert H.

Journal:

Regulatory Toxicology and Pharmacology

Year:

2019

Language:

english

File:

PDF, 1.82 MB

english, 2019

8

An update on the hazard of and exposure to diethyl hexyl phthalate (DEHP) alternatives used in medical devices

Den Braver-Sewradj, Shalenie P., Piersma, Aldert, Hessel, Ellen V. S.

Journal:

Critical Reviews in Toxicology

Year:

2020

File:

PDF, 1.84 MB

2020

9

Dose–response analysis of phthalate effects on gene expression in rat whole embryo culture

Joshua F. Robinson, Aart Verhoef, Vincent A. van Beelen, Jeroen L.A. Pennings, Aldert H. Piersma

Journal:

Toxicology and Applied Pharmacology

Year:

2012

Language:

english

File:

PDF, 635 KB

english, 2012

10

The Urgency for Optimization and Harmonization of Thyroid Hormone Analyses and Their Interpretation in Developmental and Reproductive Toxicology Studies

Beekhuijzen, Manon, Schneider, Steffen, Barraclough, Narinder, Hallmark, Nina, Hoberman, Alan, Lordi, Sheri, Moxon, Mary, Perks, Deborah, Piersma, Aldert H., Makris, Susan L.

Journal:

Reproductive Toxicology

Year:

2018

Language:

english

File:

PDF, 341 KB

english, 2018

11

A plea for risk assessment of endocrine disrupting chemicals

Testai, Emanuela, Galli, Corrado L., Dekant, Wolfgang, Marinovich, Marina, Piersma, Aldert H., Sharpe, Richard M.

Journal:

Year:

2013

Language:

english

File:

PDF, 663 KB

english, 2013

12

Implementation of toxicokinetics in toxicity studies – Toxicokinetics of 4-methylanisole and its metabolites in juvenile and adult rats

Brandon, Esther F.A., van Kesteren, Petra C.E., van Eijkeren, Jan C.H., Tienstra, Marc, Sanchez, Patricia Lopez, Tonk, Elisa C.M., Piersma, Aldert H., Bos, Peter M.J.

Journal:

Regulatory Toxicology and Pharmacology

Year:

2015

Language:

english

File:

PDF, 945 KB

english, 2015

13

The virtual human in chemical safety assessment

Piersma, Aldert H., van Benthem, Jan, Ezendam, Janine, Staal, Yvonne CM., Kienhuis, Anne S.

Journal:

Current Opinion in Toxicology

Year:

2019

Language:

english

File:

PDF, 1.24 MB

english, 2019

14

State of the art in developmental toxicity screening methods and a way forward: a meeting report addressing embryonic stem cells, whole embryo culture, and zebrafish

Robert Chapin, Karen Augustine-Rauch, Bruce Beyer, George Daston, Richard Finnell, Thomas Flynn, Sidney Hunter, Phillip Mirkes, K. Sue O'Shea, Aldert Piersma, David Sandler, Philippe Vanparys, Geneviè

Journal:

Birth Defects Research Part B: Developmental and Reproductive Toxicology

Year:

2008

Language:

english

File:

PDF, 282 KB

english, 2008

15

Retrospective analysis of relative parameter sensitivity in multi-generation reproductive toxicity studies

Zhi-Chao Dang, Emiel Rorije, Thijs Hogen Esch, André Muller, Betty C. Hakkert, Aldert H. Piersma

Journal:

Reproductive Toxicology

Year:

2009

Language:

english

File:

PDF, 835 KB

english, 2009

16

Triazole induced concentration-related gene signatures in rat whole embryo culture

Joshua F. Robinson, Elisa C.M. Tonk, Aart Verhoef, Aldert H. Piersma

Journal:

Reproductive Toxicology

Year:

2012

Language:

english

File:

PDF, 558 KB

english, 2012

17

Juvenile toxicity testing protocols for chemicals

Aldert H. Piersma, Elisa C.M. Tonk, Susan L. Makris, Kevin M. Crofton, Rodney R. Dietert, Henk van Loveren

Journal:

Reproductive Toxicology

Year:

2012

Language:

english

File:

PDF, 186 KB

english, 2012

18

Using adverse outcome pathway genes to assess developmental toxicity of compounds in a mouse stem cell system

Teunis, Marc A.T., Fiechter, Danielle, Mika, Paulina, Theunissen, Peter T., Hendriks, Giel, Krul, Cyrille A.M., Piersma, Aldert H.

Journal:

Toxicology Letters

Year:

2013

Language:

english

File:

PDF, 69 KB

english, 2013

19

Adverse outcome pathway based battery approaches in an alternative strategy for reproductive toxicity testing

Piersma, Aldert H.

Journal:

Reproductive Toxicology

Year:

2014

Language:

english

File:

PDF, 48 KB

english, 2014

20

Evaluation of an alternative in vitro test battery for detecting reproductive toxicants in a grouping context

Kroese, E. Dinant, Bosgra, Sieto, Buist, Harrie E., Lewin, Geertje, van der Linden, Sander C., Man, Hai-yen, Piersma, Aldert H., Rorije, Emiel, Schulpen, Sjors H.W., Schwarz, Michael, Uibel, Frederik,

Journal:

Reproductive Toxicology

Year:

2015

Language:

english

File:

PDF, 372 KB

english, 2015

21

Flusilazole induces spatio-temporal expression patterns of retinoic acid-, differentiation- and sterol biosynthesis-related genes in the rat Whole Embryo Culture

Dimopoulou, Myrto, Verhoef, Aart, van Ravenzwaay, Bennard, Rietjens, Ivonne M.C.M., Piersma, Aldert H.

Journal:

Reproductive Toxicology

Year:

2016

Language:

english

File:

PDF, 615 KB

english, 2016

22

A transcriptomic analysis for classifying six azoles regarding their embryotoxic potency in the rat Whole Embryo Culture

Dimopoulou, Myrto, Verhoef, Aart, Pennings, Jeroen, van Ravenzwaay, Bennard, Rietjens, Ivonne M.C.M., Piersma, Aldert H.

Journal:

Reproductive Toxicology

Year:

2016

Language:

english

File:

PDF, 102 KB

english, 2016

23

Validation redefined

Piersma, Aldert H., van Benthem, Jan, Ezendam, Janine, Kienhuis, Anne S.

Journal:

Toxicology in Vitro

Year:

2018

Language:

english

File:

PDF, 175 KB

english, 2018

24

Measurement and evaluation of neurobehavioral effects induced by tetrabromobisphenol A (TBBPA)—Response to

Hellmuth Lilienthal, Wout Slob, Leo T.M. van der Ven, Aldert H. Piersma

Journal:

Year:

2009

Language:

english

File:

PDF, 181 KB

english, 2009

25

Developmental immunotoxicity of methylmercury: The relative sensitivity of developmental and immune parameters

Elisa C.M. Tonk, Didima M.G. de Groot, André H. Penninks, Ine D.H. Waalkens-Berendsen, André P.M. Wolterbeek, Aldert H. Piersma, Henk van Loveren

Journal:

Reproductive Toxicology

Year:

2009

Language:

english

File:

PDF, 269 KB

english, 2009

26

An adverse outcome pathway framework for neural tube and axial defects mediated by modulation of retinoic acid homeostasis

Tonk, Elisa C.M., Pennings, Jeroen L.A., Piersma, Aldert H.

Journal:

Reproductive Toxicology

Year:

2015

Language:

english

File:

PDF, 1.83 MB

english, 2015

27

Implementation of toxicokinetics in toxicity studies – Example of 4-methylanisole

van Kesteren, Petra, Brandon, Esther, Piersma, Aldert, Bos, Peter

Journal:

Toxicology Letters

Year:

2017

File:

PDF, 81 KB

2017

28

Testing developmental toxicity in a second species: are the differences due to species or replication error?

Braakhuis, Hedwig M., Theunissen, Peter T., Slob, Wout, Rorije, Emiel, Piersma, Aldert H.

Journal:

Regulatory Toxicology and Pharmacology

Year:

2019

File:

PDF, 1.82 MB

2019

29

Subacute effects of the brominated flame retardants hexabromocyclododecane and tetrabromobisphenol A on hepatic cytochrome P450 levels in rats

Silke Germer, Aldert H. Piersma, Leo van der Ven, Andreas Kamyschnikow, Yvonne Fery, Hans-Joachim Schmitz, Dieter Schrenk

Journal:

Year:

2006

Language:

english

File:

PDF, 224 KB

english, 2006

30

The embryonic stem cell test combined with toxicogenomics as an alternative testing model for the assessment of developmental toxicity

Dorien A.M. van Dartel, Aldert H. Piersma

Journal:

Reproductive Toxicology

Year:

2011

Language:

english

File:

PDF, 319 KB

english, 2011

31

Chemical class-specific gene expression changes in the zebrafish embryo after exposure to three glycol ether alkoxy acids and two 1,2,4-triazole antifungals

Sanne A.B. Hermsen, Tessa E. Pronk, Evert-J. van den Brandhof, Leo T.M. van der Ven, Aldert H. Piersma

Journal:

Reproductive Toxicology

Year:

2011

Language:

english

File:

PDF, 248 KB

english, 2011

32

Developmental toxicity of butyl benzyl phthalate in the rat using a multiple dose study design

Aldert H. Piersma, Aart Verhoef, JanDirk te Biesebeek, Moniek N. Pieters, Wout Slob

Journal:

Reproductive Toxicology

Year:

2000

Language:

english

File:

PDF, 475 KB

english, 2000

33

A statistical approach towards the derivation of predictive gene sets for potency ranking of chemicals in the mouse embryonic stem cell test

Schulpen, Sjors H.W., Pennings, Jeroen L.A., Tonk, Elisa C.M., Piersma, Aldert H.

Journal:

Toxicology Letters

Year:

2014

Language:

english

File:

PDF, 1.22 MB

english, 2014

34

Dynamic changes in energy metabolism upon embryonic stem cell differentiation support developmental toxicant identification

van Dartel, Dorien A.M., Schulpen, Sjors H., Theunissen, Peter T., Bunschoten, Annelies, Piersma, Aldert H., Keijer, Jaap

Journal:

Year:

2014

Language:

english

File:

PDF, 1.29 MB

english, 2014

35

The Practical Application of Three Validated In Vitro Embryotoxicity Tests

Spielmann, Horst, Seiler, Andrea, Bremer, Susanne, Hareng, Lars, Hartung, Thomas, Ahr, Hans, Faustman, Elaine, Haas, Ulla, Moffat, Graeme J., Nau, Heinz, Vanparys, Philippe, Piersma, Aldert, Sintes, J

Journal:

Alternatives to laboratory animals : ATLA

Year:

2006

Language:

english

File:

PDF, 115 KB

english, 2006

36

A retrospective analysis of developmental toxicity studies in rat and rabbit: What is the added value of the rabbit as an additional test species?

Gemma Janer, Wout Slob, Betty C. Hakkert, Theo Vermeire, Aldert H. Piersma

Journal:

Regulatory Toxicology and Pharmacology

Year:

2008

Language:

english

File:

PDF, 198 KB

english, 2008

37

The safety of the use of bisphenol A in medical devices

Testai, Emanuela, Hartemann, Philippe, Rodríguez-Farre, Eduardo, Rastogi, Suresh Chandra, Bustos, Juana, Gundert-Remy, Ursula, Hensten, Arne, Kopperud, Hilde Molvig, Olea, Nicolás, Piersma, Aldert, De

Journal:

Regulatory Toxicology and Pharmacology

Year:

2016

Language:

english

File:

PDF, 156 KB

english, 2016

38

RECOVERY OF HEMOPOIETIC STROMAL PROGENITOR CELLS AFTER LETHAL TOTAL-BODY IRRADIATION AND BONE MARROW TRANSPLANTATION IN MICE

PIERSMA, ALDERT H., BROCKBANK, KELVIN G. M., PLOEMACHER, ROB E., OTTENHEIM, CECILE P. E.

Journal:

Transplantation Journal

Year:

1985

File:

PDF, 371 KB

1985

39

Subacute effects of hexabromocyclododecane (HBCD) on hepatic gene expression profiles in rats

Rocío F. Cantón, Ad A.C.M. Peijnenburg, Ron L.A.P. Hoogenboom, Aldert H. Piersma, Leo T.M. van der Ven, Martin van den Berg, Marjoke Heneweer

Journal:

Toxicology and Applied Pharmacology

Year:

2008

Language:

english

File:

PDF, 351 KB

english, 2008

40

Osteoblast differentiation of murine embryonic stem cells as a model to study the embryotoxic effect of compounds

Esther de Jong, Lianne van Beek, Aldert H. Piersma

Journal:

Toxicology in Vitro

Year:

2012

Language:

english

File:

PDF, 884 KB

english, 2012

41

Serum concentrations of polybrominated diphenyl ethers (PBDEs) and a polybrominated biphenyl (PBB) in men from Greenland, Poland and Ukraine

Lenters, Virissa, Thomsen, Cathrine, Smit, Lidwien A.M., Jönsson, Bo A.G., Pedersen, Henning S., Ludwicki, Jan K., Zviezdai, Valentyna, Piersma, Aldert H., Toft, Gunnar, Bonde, Jens Peter, Becher, Geo

Journal:

Environment International

Year:

2013

Language:

english

File:

PDF, 731 KB

english, 2013

42

Lasting Effects on Body Weight and Mammary Gland Gene Expression in Female Mice upon Early Life Exposure to n-3 but Not n-6 High-Fat Diets

Luijten, Mirjam, Singh, Amar V., Bastian, Caleb A., Westerman, Anja, Pisano, M. Michele, Pennings, Jeroen L. A., Verhoef, Aart, Green, Maia L., Piersma, Aldert H., de Vries, Annemieke, Knudsen, Thomas

Journal:

Year:

2013

Language:

english

File:

PDF, 618 KB

english, 2013

43

Developmental stage-specific gene regulation in the rat whole embryo culture induced by Flusilazole

Dimopoulou, Myrto, Verhoef, Aart, van Ravenzwaay, Bennard, Rietjens, Ivonne M.C.M., Piersma, Aldert H.

Journal:

Reproductive Toxicology

Year:

2015

Language:

english

File:

PDF, 69 KB

english, 2015

44

The safety of medical devices containing DEHP plasticized PVC or other plasticizers on neonates and other groups possibly at risk (2015 update)

Testai, Emanuela, Hartemann, Philippe, Rastogi, Suresh Chandra, Bernauer, Ulrike, Piersma, Aldert, De Jong, Wim, Gulliksson, Hans, Sharpe, Richard, Schubert, Dirk, Rodríguez-Farre, Eduardo

Journal:

Regulatory Toxicology and Pharmacology

Year:

2016

Language:

english

File:

PDF, 147 KB

english, 2016

45

Corrigendum to ‘Embryotoxic and pharmacologic potency ranking of six azoles in the rat whole embryo culture by morphological and transcriptomic analysis’ [Toxicol. Appl. Pharmacol., 322 (2017) 15–26]

Dimopoulou, Myrto, Verhoef, Aart, Pennings, Jeroen, van Ravenzwaay, Bennard, Rietjens, Ivonne M.C.M., Piersma, Aldert H.

Journal:

Toxicology and Applied Pharmacology

Year:

2018

Language:

english

File:

PDF, 118 KB

english, 2018

46

An AOP-based ontology for spina bifida caused by disturbance in retinoic acid signaling

Piersma, Aldert H., Baker, Nancy C., Burgoon, Lyle D., Daston, George, Knudsen, Thomas B., Staal, Yvonne C.M.

Journal:

Reproductive Toxicology

Year:

2018

Language:

english

File:

PDF, 51 KB

english, 2018

47

Triazole-induced gene expression changes in the zebrafish embryo

Sanne A.B. Hermsen, Tessa E. Pronk, Evert-Jan van den Brandhof, Leo T.M. van der Ven, Aldert H. Piersma

Journal:

Reproductive Toxicology

Year:

2012

Language:

english

File:

PDF, 738 KB

english, 2012

48

Proteome profiling of mouse embryonic stem cells to define markers for cell differentiation and chemical-mediated embryotoxicity

Ahmed M. Osman, Sjors H.W. Schulpen, Dorien A.M. van Dartel, Edwin Zwart, Marco Blokland, Jeroen L.A. Pennings, Aldert H. Piersma

Journal:

Reproductive Toxicology

Year:

2010

Language:

english

File:

PDF, 51 KB

english, 2010

49

Concentration-dependent gene expression responses to flusilazole in embryonic stem cell differentiation cultures

Dorien A.M. van Dartel, Jeroen L.A. Pennings, Liset J.J. de la Fonteyne, Karen J.J. Brauers, Sandra Claessen, Joost H. van Delft, Jos C.S. Kleinjans, Aldert H. Piersma

Journal:

Toxicology and Applied Pharmacology

Year:

2011

Language:

english

File:

PDF, 953 KB

english, 2011

50

A retrospective analysis of the two-generation reproductive toxicity study

Gemma Janer, Aldert H. Piersma, Betty C. Hakkert, Theo Vermeire, Wout Slob

Journal:

Toxicology Letters

Year:

2007

Language:

english

File:

PDF, 74 KB

english, 2007

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